Beating Cancer with Nutrition

Does Sugar Feed Cancer

Sugar Feeds Cancer – Nobel Prize
Nobel laureate (1931 Medicine) Otto Warburg, MD, PhD, first discovered that cancer cells have a fundamental difference in energy metabolism 2 compared to healthy undifferentiated cells. 3 Cancer cells ferment glucose anaerobically. 4 Since Warburg’s pivotal study published in Science in 1956, many other researchers have corroborated his conclusions.

“A frequent characteristic of many malignant tumors is an increase in anaerobic glycolysis, that is the conversion of glucose to lactate, when compared to normal tissues.”

“The high rate of glucose consumption by malignant cells, their heavy dependence on the inefficient glycolytic mode for energy production, their increased energy expenditures, and the susceptibility to carbohydrate deprivation prompted several attempts to exploit the tumoricidal potential of manipulations interfering with carbohydrate and/or energy metabolism, hoping that such interventions could preferentially impair the malignant cells.” 5

“In normoglycemic hosts the in vivo consumption of glucose by neoplastic tissues was found to be very high. Cerebral tissue is reported to use from 0.23 to 0.57 gm of glucose per hour per 100 gm wet brain and rates as one of the highest consumers among the normal tissues. However, hepatomas and fibrosarcomas consumed roughly as much glucose as the brain does and carcinomas about twice as much.” 6

“The glucose utilization rate in neoplastic tissues, unlike in host tissues, is high. Glucose, in fact, is the preferred energy substrate, utilized mainly via the anaerobic glycolytic pathway. The large amount of lactate produced by this process is then transported to the liver where it is converted to glucose, thus contributing to further increase host’s energy wasting.” 7

Elevated Lactate Levels

“Our laboratory has been interested in the metabolic derangements of cancer, particularly lactate overproduction, in view of our work linking lactate over-production in obesity to insulin resistance…Thus, in all four studies listed above, lactate levels were 27-83% higher in cancer patients than in related controls.” 8

Does Nutrition Affect Chemotherapy

Lower Ph Through Lactic Acid Accumulation

Since cancer cells use glucose through anaerobic fermentation, then lactic acid must accumulate as the inefficient by-product of energy metabolism. Human tumors were implanted in rats, which were then given IV solutions of glucose. pH in the tumor tissue was reduced to an average of 6.43, given the logarithmic scale of hydrogen ions in pH measurement, “This pH value corresponds to a ten-fold increase in H+ ion activity in tumor tissue as compared to arterial blood.” 9 By lowering pH in tumor cells, we can effectively create a selective systemic therapy which will kill cancer cells and not healthy tissue.

“After IV glucose, tumor acidification occurred in 9 out of 10 patients. Larger tumors tended to exhibit a greater decrease in pH…We conclude that IV and IV + oral glucose administration are equally effective at inducing tumor acute acidification.” 10

Elevated Blood Glucose May Suppress Immune Functions

Ten healthy human volunteers were assessed for fasting blood glucose levels and tumor engulfing ability of neutrophils. “Oral 100 gm portions of carbohydrates from glucose, fructose, sucrose, honey, or orange juice all significantly decreased the capacity of neutrophils to engulf bacteria as measured by the slide technique. Starch ingestion did not have this effect.” 11

Insulin-Cancer Relationship

“Insulin is a major anabolic hormone in mammals and its involvement in malignancies is well documented.” 12 Diabetics have a much higher risk for cancer. 13

Epidemiological Evidence. “Risk associated with the intake of sugars, independent of other energy sources, is more than doubled [for biliary tract cancer]”. 14 “In older women, a strong correlation was found between breast cancer mortality and sugar consumption…” 15

The Sugar Cancer Link

In most major cancer hospitals around the world, oncologists use a $2 million device, called a PET scan (positron emission tomography), which detects cancer by finding hot spots of sugar feeding cells in the body. All of these world-class scientists are using the same principle: sugar feeds cancer. When we can lower blood glucose, we can slow cancer growth.

Professor Seyfried of Boston College and Yale University has written a medical textbook showing the strong link between cancer and glucose: CANCER AS A METABOLIC DISEASE.

Control Blood and Gut Glucose to Control Cancer Studies

Simple sugars, not starches, impaired neutrophil phagocytosis.
Sanchez, A., et al., American Journal Clinical Nutrition, vol.26, p.180, 1973

Comparing 50 colorectal cancer patients to healthy controls, cancer patients ate more sugar and fat than the healthy people.
Bristol, JB, et al., Proceedings American Association of Cancer Research, vol.26, p.206, Mar.1985

In a 40 country epidemiological study, sugar consumption predicts (0.73 correl) breast cancer.
Hems, G., Br.J.Cancer, vol.37, p.974, 1978

Animals were fed isocaloric diets of sugar or starch carbohydrates. The group eating more sugar developed significantly more mammary tumors than the starch-fed group.
Hoehn, SK, et al., Nutrition & Cancer, vol.1, no.3, p.27, Spring 1979

Animals w.implanted breast cancer survived longest with diet that lowered blood glucose.
Santisteban, Biochem.& BiophysRes. Comm., vol.132, no.3, p.1174, 1985

Insulin is a major anabolic hormone in mammals and its involvement in malignancies is well documented.
Yam, D., Med.Hypotheses, vol.38, p.111, 1992

Tumors are Sugar Feeders

Tumors are primarily obligate glucose metabolizers, meaning “sugar feeders”. 16 The average American consumes 20% of calories from refined white sugar, which is more of a drug than a food. We also manifest poor glucose tolerance due to stress, obesity, low chromium and fiber intake, and sedentary lifestyles. Blood glucose is basically there to feed the brain and other glucose-dependent organs, while also supplying fuel for muscle movement.

When we sit all day, the sugar in our blood is like a teenager with nothing to do–trouble is bound to happen. Elevated sugar levels in the blood will “tan” proteins (glycosylation), which makes immune cells and red blood cells less capable of doing their jobs. Elevated sugar in the blood has a number of ways in which it promotes cancer:

Cancer cells primarily use glucose for fuel. This inefficient pathway for energy metabolism yields only 5% of the ATP energy available in food, which is one of the reasons why 40% of cancer patients die from malnutrition or cachexia. Cancer therapies need to regulate blood glucose levels via diet, intermittent fasting, supplements, enteral and parenteral solutions for cachectic patients, medication, exercise, gradual weight loss, stress reduction, etc.

Does Fruit Feed Cancer Cells

Given the abundant scientific data supporting the sugar-cancer link, many people have been quick to discourage the consumption of fruit. Throughout human history, fruit has been the ultimate health food, until the paleo and keto diet trends set in. There is abundant misinformation that fruits are harmful since fruits contain natural sugars.

While the Paleolithic and ketogenic diets have their place, they have eliminated or seriously reduced the most powerful anticancer food groups: fruit, whole grains, legumes.

In fact, ALL scientific evidence shows that whole fruits are an important part of anyone’s diet, especially the cancer patient. Whole fruits are a rich mixture of vitamins, minerals, bioflavonoids, carotenoids, pectin, fiber, potassium, and promising anti-cancer agents, such as ficin in figs and phytoalexins in red fruits. The antioxidant capacity (ORAC) and laxative effect of most fruits is therapeutic for the body.

In one study, Harvard researchers followed 75,000 women for 24 years and found that 2 servings of peaches per week lowered the risk for breast cancer by 40%. 17 In another study, Harvard researchers studied 44,000 men in Hawaii. The more fruit they ate, the lower the risk for cancer; in a dose dependent fashion. 18

Fruit is Primal Human Food

Fact is, fruit, eggs, and insects were the original caveman food, when intelligence and tools limited what was available to eat. Red and green fruits and vegetables, garlic and cabbage family contain phytoalexins, which have powerful anti-cancer and anti-fungal activity. Here is where you begin to appreciate the brilliant design of nature. Fruit contains sugar, which fungus and insects would love to eat. Hence, fruits could only survive by producing substances that inhibit fungal growth, insects, etc. Is cancer a fungal infection?

Control Gut and Blood Glucose

Control gut and blood glucose through diet (no refined carbs), supplements (i.e. cinnamon, chromium, vanadium, magnesium), stress reduction (cortisol can increase blood glucose), exercise, and intermittent fasting.

“Insulin is a major anabolic hormone in mammals and its involvement in malignancies is well documented.” 12 Diabetics have a much higher risk for cancer. 13

Epidemiological Evidence. “Risk associated with the intake of sugars, independent of other energy sources, is more than doubled [for biliary tract cancer]”. 14 “In older women, a strong correlation was found between breast cancer mortality and sugar consumption…” 15

By Patrick Quillin, PhD,RD,CNS
Excerpted from Beating Cancer with Nutrition

1 https://www.dhhs.nh.gov/dphs/nhp/documents/sugar.pdf
2 https://link.springer.com/article/10.1007/s10863-007-9086-x
3 https://www.ingentaconnect.com/content/ben/acamc/2008/00000008/00000003/art00006
4 Warburg, O., Science, vol.123, no.3191, p.309, Feb.1956
5 Demetrakopoulos, GE, Cancer Research, vol.42, p.756S, Feb.1982
6 Gullino, PM, Cancer Research, vol.27,p.1031, June 1967
7 Rossi-Fanelli, F., J.Parenteral Enteral Nutr., vol.15, p.680, 1991
8 Digirolamo, M., in DIET AND CANCER: MARKERS, PREVENTION, AND TREATMENT, p.203, Plenum
Press, NY, 1994
9 Volk, T., Br.J.Cancer, vol.68, p.492, 1993
10 Leeper, DB, Int.J.Hyperthermia, vol.14, no.3, p.257, 1998
11 Sanchez, A., Amer.J.Clin.Nutr., vol.26, p.1180, Nov.1973
12 Yam, D., Medical Hypotheses, vol.38, p.111, 1992
13 https://www.nature.com/articles/6605240
14 Moerman, CJ, Int.J.Epidemiology, vol.22, no.2, p.207, 1993
15 Seeley,S.,, Med.Hypotheses, vol.11, p.319, 1983
16 Rothkopf, M, Fuel utilization in neoplastic disease: implications for the use of nutritional support in cancer
patients, Nutrition, supp, 6:4:14-16S, 1990
17 https://link.springer.com/article/10.1007/s10549-013-2484-3
18 http://cancerres.aacrjournals.org/content/58/3/442

 

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Beating Cancer with Nutrition